Research Interests: Development of biology-inspired electrochemical sensors to enable 1) direct detection of disease markers and drugs in biological fluids for decentralized health monitoring and 2) continuous, real-time measurements of molecules in situ in the body.
Research Interests: Chemical, biochemical, and biological studies on nucleic acid damage and DNA repair in free DNA and nucleosomes, design of radiosensitizing agents, inhibitors of DNA repair enzymes, and molecules that enable the spatiotemporal control of nucleic acid structure
Research Interests: Biology behind poly(ADP-ribose) (PAR)—the third polynucleotide besides DNA and RNA. Research includes (1) developing new chemical and proteomics tools to study PAR, (2) identifying predictive biomarkers for cancer therapy with PAR polymerase (PARP) inhibitors, and (3) discovering novel roles of PAR in non-coding RNA biology and non-membranous cellular structures
Research Interests: Engineering new proteins that modulate the immune response for targeted disease therapy. Synthesizing tools and techniques from structural biology, molecular engineering, and translational immunology, the Spangler lab seeks to understand the mechanisms underlying protein activity in order to design effective immunotherapeutics.
Research Interests: Develops and applies the protein chip technology to investigate important biological questions and to help clinical research. Research focus includes networks and pathways of protein posttranslational modifications, gene transcription regulatory networks, pathogen-host interaction networks, and biomarker discovery.