- Research Interests: Development of biology-inspired electrochemical sensors to enable 1) direct detection of disease markers and drugs in biological fluids for decentralized health monitoring and 2) continuous, real-time measurements of molecules in situ in the body.
- Research Interests: Structure/function studies of genome integrity
- Research Interests: Medicinal chemistry and drug discovery, especially for diseases of the central nervous system
- Research Interests: Structural and catalytic mechanisms of nucleic-acid machines and assemblies; control of DNA replication and chromosome superstructure; small-molecule and biological regulatory mechanisms.
- Research Interests: Coupling biochemistry and structural biology (crystallography/cryoEM) to reveal mechanisms by which ATP-dependent remodeling enzymes and transcription factors alter nucleosome structure and dynamics.
- Research Interests: Cellular transport and trafficking of heavy metals, antioxidant enzymes
- Research Interests: Folding and assembly of proteins and molecular machines in vivo; crosslinking mass spectrometry; ancient proteins and the origins of life; synthetic biology and directed evolution
- Research Interests: Applying NMR spectroscopy to the study of protein motions in large molecules
Bethany Powell Gray
- Research Interests: Nucleic acid chemistry and biology in order to create safer drugs and tunable imaging agents for disease detection
- Research Interests: Chemical, biochemical, and biological studies on nucleic acid damage and DNA repair in free DNA and nucleosomes, design of radiosensitizing agents, inhibitors of DNA repair enzymes, and molecules that enable the spatiotemporal control of nucleic acid structure
- Research Interests: Structural and dynamic basis for molecular recognition, catalysis, and allostery
- Research Interests: Chemistry at biological interfaces, cell signaling, biochemistry of membrane proteins, quantitative fluorescence microscopy.
- Research Interests: Our lab harnesses the power of directed evolution to develop new enzymes to solve outstanding problems at the frontiers of chemistry and biology
- Research Interests: Protein folding, translation and translocation with single-molecule approaches
- Research Interests: Structural and biochemical studies of the molecular mechanisms of signaling pathways
- Research Interests: Determinants of protein structure and dynamics in solution; NMR spectroscopy of heme proteins
- Research Interests: Biology behind poly(ADP-ribose) (PAR)—the third polynucleotide besides DNA and RNA. Research includes (1) developing new chemical and proteomics tools to study PAR, (2) identifying predictive biomarkers for cancer therapy with PAR polymerase (PARP) inhibitors, and (3) discovering novel roles of PAR in non-coding RNA biology and non-membranous cellular structures
- Research Interests: Use of small molecules as probes to elucidate mechanisms of signal transduction; angiogenesis and cell proliferation
Caren Freel Meyers
- Research Interests: Development of antibiotic prodrug strategies; study of bacterial isoprenoid and vitamin biosynthesis as antibacterial targets
- Research Interests: Protein engineering, directed evolution, allostery
- Research Interests: Redox signaling during aging and neurodegeneration
- Research Interests: essential nutrients and metabolic pathways in malaria parasites
- Research Interests: Sequence and conformation specific reactions of nucleic acids; enzyme-mediated activation of substrates and coenzymes for dehalogenation
- Research Interests: Cell surface molecular interactions (cell-cell recognition) and the control of cell behaviors in the nervous system (axon regeneration) and immune system (inflammation); Glycobiology
- Research Interests: In vitro synthetic biology for the design synthetic devices, materials and cells using ideas from DNA nanotechnology and systems chemistry
- Research Interests: Mechanistic enzymology and X-ray crystallography; structure and function of allosterically regulated biological stress-sensors
- Research Interests: Engineering new proteins that modulate the immune response for targeted disease therapy. Synthesizing tools and techniques from structural biology, molecular engineering, and translational immunology, the Spangler lab seeks to understand the mechanisms underlying protein activity in order to design effective immunotherapeutics.
- Research Interests: The fundamental chemistry and biology of physiologically important signaling molecules including nitroxyl (HNO), hydrogen sulfide (H2S) and related reactive sulfur species including hydropersulfides (RSSH)
- Research Interests: Natural product chemistry, enzymology and molecular biology, fatty acid synthase inhibitors for cancer, tuberculosis and obesity
- Research Interests: Biochemical, biophysical and structural studies on enzymes involved in ubiquitin signaling and transcription regulation
- Research Interests: RNA folding and catalysis; dynamics of small regulatory RNAs; mechanism of 30S ribosome assembly by time resolved footprinting
- Research Interests: Develops and applies the protein chip technology to investigate important biological questions and to help clinical research. Research focus includes networks and pathways of protein posttranslational modifications, gene transcription regulatory networks, pathogen-host interaction networks, and biomarker discovery.
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