faculty
Netz Arroyo
Contact Information
- netzarroyo@jhmi.edu
- 443-287-4798
Research Interests: Development of biology-inspired electrochemical sensors to enable 1) direct detection of disease markers and drugs in biological fluids for decentralized health monitoring and 2) continuous, real-time measurements of molecules in situ in the body.
Scott Bailey
Contact Information
- scott.bailey@jhu.edu
- 443-756-6791
Research Interests: Structure/function studies of genome integrity
James Barrow
Contact Information
- jbarrow@jhmi.edu
- 410-955-0894
Research Interests: Medicinal chemistry and drug discovery, especially for diseases of the central nervous system
James Berger
Contact Information
- jmberger@jhmi.edu
- 410-955-7163
Research Interests: Structural and catalytic mechanisms of nucleic-acid machines and assemblies; control of DNA replication and chromosome superstructure; small-molecule and biological regulatory mechanisms.
Greg Bowman
Contact Information
- gdbowman@jhu.edu
- 410-516-7850
Research Interests: Coupling biochemistry and structural biology (crystallography/cryoEM) to reveal mechanisms by which ATP-dependent remodeling enzymes and transcription factors alter nucleosome structure and dynamics.
Valeria Culotta
Contact Information
- vculott1@jhu.edu
- 410-955-3029
Research Interests: Cellular transport and trafficking of heavy metals, antioxidant enzymes
Stephen Fried
Contact Information
- sdfried@jhu.edu
- 410-516-7835
Research Interests: Folding and assembly of proteins and molecular machines in vivo; crosslinking mass spectrometry; ancient proteins and the origins of life; synthetic biology and directed evolution
Dominique Frueh
Contact Information
- dfrueh1@jhmi.edu
- 410-614-4719
Research Interests: Applying NMR spectroscopy to the study of protein motions in large molecules
David Goldberg
Contact Information
- dpg@jhu.edu
- 410-516-6658
Research Interests: Bioinorganic chemistry, synthetic analogs of metalloenzymes, synthesis and reactivity of heme and nonheme transition metal complexes, biomimetic small molecule activation (e.g. dioxygen, nitric oxide, hydrogen sulfide)
Bethany Powell Gray
Contact Information
- bethany.gray@jhmi.edu
- 410-502-0844
Research Interests: Nucleic acid chemistry and biology in order to create safer drugs and tunable imaging agents for disease detection
Marc Greenberg
Contact Information
- mgreenberg@jhu.edu
- 410-516-8095
Research Interests: Chemical, biochemical, and biological studies on nucleic acid damage and DNA repair in free DNA and nucleosomes, design of radiosensitizing agents, inhibitors of DNA repair enzymes, and molecules that enable the spatiotemporal control of nucleic acid structure
Vincent Hilser
Contact Information
- hilser@jhu.edu
- 410-516-6072
Research Interests: Structural and dynamic basis for molecular recognition, catalysis, and allostery
Kalina Hristova
Contact Information
- kalina.hristova@jhu.edu
- 410-516-8939
Research Interests: Chemistry at biological interfaces, cell signaling, biochemistry of membrane proteins, quantitative fluorescence microscopy.
Xiongyi Huang
Contact Information
- xiongyi@jhu.edu
- 410-516-1181
Research Interests: Our lab harnesses the power of directed evolution to develop new enzymes to solve outstanding problems at the frontiers of chemistry and biology
Jennifer Kavran
Contact Information
- jkavran@jhu.edu
- 410-955-3671
Research Interests: Structural and biochemical studies of the molecular mechanisms of signaling pathways
Anthony Leung
Contact Information
- aleung6@jhu.edu
- 410-502-8939
Research Interests: Biology behind poly(ADP-ribose) (PAR)—the third polynucleotide besides DNA and RNA. Research includes (1) developing new chemical and proteomics tools to study PAR, (2) identifying predictive biomarkers for cancer therapy with PAR polymerase (PARP) inhibitors, and (3) discovering novel roles of PAR in non-coding RNA biology and non-membranous cellular structures
Jun Liu
Contact Information
- joliu@jhu.edu
- 410-955-4619
Research Interests: Use of small molecules as probes to elucidate mechanisms of signal transduction; angiogenesis and cell proliferation
Caren Freel Meyers
Contact Information
- cmeyers@jhmi.edu
- 410-502-4807
Research Interests: Development of antibiotic prodrug strategies; study of bacterial isoprenoid and vitamin biosynthesis as antibacterial targets
Marc Ostermeier
Contact Information
- osterm@jhu.edu
- 410-516-7144
Research Interests: Protein engineering, directed evolution, allostery
Bindu Paul
Contact Information
- bpaul8@jhmi.edu
- 443-287-4821
Research Interests: Redox signaling during aging and neurodegeneration
Sean Prigge
Contact Information
- sprigge2@jhu.edu
- 443-287-4822
Research Interests: essential nutrients and metabolic pathways in malaria parasites
Steve Rokita
Contact Information
- rokita@jhu.edu
- 410-516-5793
Research Interests: Sequence and conformation specific reactions of nucleic acids; enzyme-mediated activation of substrates and coenzymes for dehalogenation
Ron Schnaar
Contact Information
- schnaar@jhu.edu
- 410-955-8392
Research Interests: Cell surface molecular interactions (cell-cell recognition) and the control of cell behaviors in the nervous system (axon regeneration) and immune system (inflammation); Glycobiology
Rebecca Schulman
Contact Information
- rschulm3@jhu.edu
- 410-516-8457
Research Interests: In vitro synthetic biology for the design synthetic devices, materials and cells using ideas from DNA nanotechnology and systems chemistry
Jungsan Sohn
Contact Information
- jsohn@jhmi.edu
- 410-614-6134
Research Interests: Mechanistic enzymology and X-ray crystallography; structure and function of allosterically regulated biological stress-sensors
Jamie Spangler
Contact Information
- jamie.spangler@jhu.edu
- 443-287-1708
Research Interests: Engineering new proteins that modulate the immune response for targeted disease therapy. Synthesizing tools and techniques from structural biology, molecular engineering, and translational immunology, the Spangler lab seeks to understand the mechanisms underlying protein activity in order to design effective immunotherapeutics.
John Toscano
Contact Information
- jtoscano@jhu.edu
- 410-516-8215
Research Interests: The fundamental chemistry and biology of physiologically important signaling molecules including nitroxyl (HNO), hydrogen sulfide (H2S) and related reactive sulfur species including hydropersulfides (RSSH)
Craig Townsend
Contact Information
- ctownsend@jhu.edu
- 410-516-7444
Research Interests: Natural product chemistry, enzymology and molecular biology, fatty acid synthase inhibitors for cancer, tuberculosis and obesity
Cynthia Wolberger
Contact Information
- cwolberg@jhmi.edu
- 410-955-0728
Research Interests: Biochemical, biophysical and structural studies on enzymes involved in ubiquitin signaling and transcription regulation
Sarah Woodson
Contact Information
- swoodson@jhu.edu
- 410-516-2015
Research Interests: RNA folding and catalysis; dynamics of small regulatory RNAs; mechanism of 30S ribosome assembly by time resolved footprinting
Heng Zhu
Contact Information
- hzhu4@bs.jhmi.edu
- 410-502-0878
Research Interests: Develops and applies the protein chip technology to investigate important biological questions and to help clinical research. Research focus includes networks and pathways of protein posttranslational modifications, gene transcription regulatory networks, pathogen-host interaction networks, and biomarker discovery.