Sample publications from CBI students and affiliates.


Aggarwal SC, Khodade VS, Porche S, Pharoah BM, Toscano JP. (2022) Photochemical Release of Hydropersulfides. J Org Chem. 87:12644-12652.  PMID: 36084133

Hauk P, Weeks R, Ostermeier M. (2023) “A CRISPR/dCas9 system for assaying and selecting for RNase III activity in vivo in E. coli” CRISPR Journal. 6:43-51. PMID: 36493370

Koyzyrev A, Lemen D, Dunn J, Rokita SE (2023) Substrate Electronics Dominate the Rate of Reductive Dehalogenation Promoted by the Flavin-Dependent Iodotyrosine Deiodinase. Biochemistry. 62:1298-1306. PMID: 36892456

Pal P, Alley JR, Townsend CA (2023) Examining Heterodimerization by Aryl C-N Coupling in Dynemicin Biosynthesis ACS Chem Biol. 18:304-314. PMID: 36696117

Pharoah BM, Zhang C, Khodade VS, Keceli G, McGinity C, Paolocci N, Toscano JP. (2023)  Hydropersulfides (RSSH) attenuate doxorubicin-induced cardiotoxicity while boosting its anticancer action.  Redox Biol. 60:102625. PMID: 36773545

Pharoah BM, Khodade VS, Eremiev A, Bao E, Liu T, O’Rourke B, Paolocci N, Toscano JP. (2022) Hydropersulfides (RSSH) Outperform Post-Conditioning and Other Reactive Sulfur Species in Limiting Ischemia-Reperfusion Injury in the Isolated Mouse Heart. Antioxidants 11:1010. PMID: 35624878

Weeks R, Ostermeier M, (2023)  Fitness and Functional Landscapes of the E. coli RNase III Gene rnc. Mol Biol Evol. 40:msad047. PMID: 36848192


Bae H, Viennet T, Park E, Chu N, Salguero A, Eck MJ, Arthanari H, Cole PA. (2022) PH domain-mediated autoinhibition and oncogenic activation of Akt. eLife 11:e80148. PMID: 35968932

Chandler CE, Hernandez FG, Totten M, Robinett NG, Schatzman SS, Zhang SX, Culotta VC. (2022) Biochemical Analysis of CaurSOD4, a Potential Therapeutic Target for the Emerging Fungal Pathogen Candida auris. 8:584-595. PMID: 35179882

Clark V, Waters K, Orsburn B. Bumpus NN, Kundu N, Sczepanski, JT, Ray P, , Arroyo-Currás, N. (2022) Human Cyclophilin B Nuclease Activity Revealed via Nucleic Acid-Based Electrochemical Sensors” Angew, Chem. Int. Ed. 61: e202211292 PMID: 35999181

Chandler CE, Hernandez FG, Totten M, Robinett NG, Schatzman SS, Zhang SX, Culotta VC. (2022) Biochemical Analysis of CaurSOD4, a Potential Therapeutic Target for the Emerging Fungal Pathogen Candida auris. ACS Infect. Dis. 8:584-595. PMID: 35179882

Dorado, TE, de León P, Begum A, Liu H, Chen D, Rajeshkumar  NV, Rey-Rodriguez R, Hoareau-Aveilla C, Alcouffe C, Laiho M,  Barrow JC (2022) Discovery and Evaluation of Novel Angular Fused Pyridoquinazolinonecarboxamides as RNA Polymerase I Inhibitors ACS Med Chem Lett. 18:608-614 PMID 35450366

Gao J, Mewborne QT, Girdhar A, Sheth U, Coyne AN, Punathil R, Kang BG, Dasovich M, Veire A, DeJesus Hernandez M, Liu S, Shi Z, Dafinca R, Fouquerel E, Talbot K, Kam TI, Zhang YJ, Dickson D, Petrucelli L, van Blitterswijk M, Guo L, Dawson TM, Dawson VL, Leung AKL, Lloyd TE, Gendron TF, Rothstein JD, Zhang K. (2022) Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins. Sci Transl Med 14(662):eabq3215. PMID: 36103513

Knox HL, Sinner EK, Townsend CA, Boal AK, Booker SJ. (2022)  Structure of a B12-dependent radical SAM enzyme in carbapenem biosynthesis. Nature 602:343-348. PMID: 35110734

Koehler TJ, Tran T, Weingartner KA, Kavran JM (2022) Kinetic Regulation of the Mammalian Sterile 20-like Kinase 2 (MST2) Biochemistry 61:1683-1693. PMID: 35895874

Kuttiyatveetil JRA, Soufari H, Dasovich M, Uribe IR, Mirhasan M, Cheng SJ, Leung AKL, Pascal JM. (2022)  Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a distinctive mode of engaging poly(ADP-ribose), Cell Rep. 41:111529. PMID: 36288691

Lichstrahl MS, Townsend CA, Sinner EK. (2022) Stereochemical course of cobalamin-dependent radical SAM methylation by TokK and ThnK. RSC Chem Biol. 3:1028-1034.  PMID: 36042702

Lombardi PM, Haile S, Rusanov T, Rodell R, Anoh R, Baer JG, Burke KA, Gray LN, Hacker AR, Kebreau KR, Ngandu CK, Orland HA, Osei-Asante E, Schmelyun DP, Shorb DE, Syed SH, Veilleux JM, Majumdar A, Mosammaparast N, Wolberger C. (2022) The ASCC2 CUE domain in the ALKBH3-ASCC DNA repair complex recognizes adjacent ubiquitins in K63-linked polyubiquitin. J. Biol. Chem. 298:101545. PMID: 34971705

Luly KM, Yang H, Lee SJ, Wang W, Ludwig SD, Tarbox HE, Wilson DR, Green JJ, Spangler JB. (2022) Poly(Beta-Amino Ester)s as High-Yield Transfection Reagents for Recombinant Protein Production. Int J Nanomedicine 17:4469-4479. PMID: 36176585

Rhine K, Dasovich M, Yoniles J, Badiee M, Skanchy S, Ganser LR, Ge Y, Fare CM, Shorter J, Leung AKL, Myong S. (2022) Poly(ADP-ribose) drives condensation of FUS via a transient interaction. Mol Cell. 2022 Mar 3;82(5):969-985.e11. PMID: 35182479

Salguero AL, Chen M, Balana AT, Chu N, Jiang H, Palanski BA, Bae H, Wright KM, Nathan S, Zhu H, Gabelli SB, Pratt MR, Cole PA.  (2022) Multifaceted Regulation of Akt by Diverse C-Terminal Post-translational Modifications. ACS Chem Biol. 17:68-76.  PMID: 34941261

Shaver A, Mahlum JD, Scida K. Johnston ML, Pellitero MA, Wu Y, Carr, GV, Arroyo-Currás, N. (2022) Optimization of Vancomycin Aptamer Sequence Length Increases the Sensitivity of Electrochemical, Aptamer-Based Sensors In Vivo. ACS Sens. 12, 3895-3905 PMID: 36417705

Sinner EK, Li R, Marous DR, Townsend CA. (2022) ThnL, a B12-dependent radical S-adenosylmethionine enzyme, catalyzes thioether bond formation in carbapenem biosynthesis. Proc Natl Acad Sci U S A. 119:e2206494119.  PMID: 35969793

Sinner EK, Marous DR, Townsend CA (2022) Evolution of Methods for the Study of Cobalamin-Dependent Radical SAM Enzymes. ACS Bio Med Chem Au 2:4-10. PMID: 35341020

Sinner EK, Townsend CA (2022) Purification and Characterization of Sequential Cobalamin-Dependent Radical SAM Methylases ThnK and TokK in Carbapenem g-Lactam Antibiotic Biosynthesis. Methods Enzymol 669:29-44. PMID: 35644176

Spisak S, O’Brien B, Ostermeier M (2022)  A bacterial dual positive and negative selection system for dCas9 activity. PLOS One. 17:e0269270.  PMID: 35657952

Wheadon MJ, Townsend CA (2022) Accurate Substrate-Like Probes for Trapping Late-Stage Intermediates in Nonribosomal Peptide Synthetase Condensation Domains. ACS Chem. Biol. 2022, 17, 8, 2046–2053 PMID: 35914245

Wheadon MJ, Townsend CA. (2022) Accurate Substrate-Like Probes for Trapping Late-Stage Intermediates in Nonribosomal Peptide Synthetase Condensation Domains.  ACS Chem Biol. 17:2046-2053. PMID: 35914245


Matyszewski M, Zheng W, Lueck J, Mazanek Z, Mohideen N, Lau AY, Egelman EH, Sohn J. (2021) Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome. Nat. Commun. 12:2735. PMID: 33980849

Mitchell J. Porter, Gao-Lan Zhang, and Ronald L. Schnaar “Ganglioside Extraction, Purification and Profiling” J Vis Exp. 2021 169: 10.3791/62385. PMCID: PMC8133307

Morgan Dasovich, Morgan Q. Beckett, Scott Bailey,Shao-En Ong, Marc M. Greenberg, and Anthony K. L. Leung.  Identifying poly(ADP-ribose)-binding proteins with photoaffinity-based proteomics JACS 2021, 143, 3037-3042.  [PMCID: PMC8109396]

Antonieta L. Salguero, Maggie Chen, Aaron T. Balana, Nam Chu, Hanjie Jiang, Brad A. Palanski, Hwan Bae, Katharine M. Wright, Sara Nathan, Heng Zhu, Sandra B. Gabelli, Matthew R. Pratt, and Philip A. Cole (2021) Multifaceted Regulation of Akt by Diverse C-Terminal Post-translational Modifications ACS Chem. Biol, in press []

D. Mahlum, Miguel Aller Pellitero, and Netzahualcóyotl Arroyo-Currás (2021) Chain Dynamics Limit Electron Transfer from Electrode-Bound, Single-Stranded Oligonucleotides  J. Phys. Chem. 125, 9038-9049 []

Yanbo Wang, Wayne Taylor Cottle, Haobo Wang, Xinyu Ashlee Feng, John Mallon, Momcilo Gavrilov, Scott Bailey and Taekjip Ha (2021) Genome oligopaint via local denaturation fluorescence in situ hybridization. Mol. Cell 81 1566-1577 []

Yanbo Wang, John Mallon, Haobo Wang, Digvijay Singh, Myung Hyun Jo, Boyang Hua, Scott Bailey and Taekjip Ha (2021) Real-time observations of Cas9 postcatalytic domain motions. Proc. Natl. Acad. Sci. USA 118, e2010650118 [ doi: 10.1073/pnas.2010650118]

Philip To, Briana Whitehead, Haley E. Tarbox, and Stephen D. Fried (2021) Nonrefoldability Is Pervasive Across the E. Coli Proteome. J. Am. Chem. Soc. 143, 11435-11448. []

Morgan Dasovich, Morgan Q. Beckett, Scott Bailey, Shao-En Ong, Marc M. Greenberg, and Anthony K. L. Leung (2021) Identifying Poly(ADP-ribose)-Binding Proteins with Photoaffinity-Based Proteomics. J Am Chem Soc.143, 3037-3042. [doi: 10.1021/jacs.0c12246]

Z. Sun, B. Xu, S. Spisak, J. M. Kavran, S. E. Rokita (2021) “The Minimal Structure for Iodotyrosine Deiodinase Function is Defined by an Outlier Pprotein from the Thermophilic Bacterium Thermotoga neapolitanaJ. Biol. Chem. 2021, 297, 101385. (DOI:

M. Dasovich, J. Zhuo, J. A. Goodman, A. Thomas, R. L. McPherson, A. K. Jayabalan, V. F. Busa, S.-J. Cheng, B. A. Murphy, K. R. Redinger, T. Tsukamoto, B. Slusher, J. Bosch, H. Wei, A. K. L. Leung,. High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain. ACS Chem. Biol. 2022, 17, 17–23. PMID: 34904435.

Edward L Huttlin, Raphael J Bruckner, Jose Navarrete-Perea , Joe R Cannon, Kurt Baltier, Fana Gebreab, Melanie P Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P Nusinow, Joao A Paulo, Devin K Schweppe, Laura Pontano Vaites, J Wade Harper, Steven P Gyg.  (2021) Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 184, 3022-3040.e28. [doi: 10.1016/j.cell.2021.04.011]

Mitchell J Porter, Gao-Lan Zhang, Ronald L Schnaar. (2021) Ganglioside Extraction, Purification and Profiling. J. Vis. Exp. 169, e62385 [doi:10.3791/62385]

Vinayak S. Khodade, Sahil C. Aggarwal, Blaze M. Pharoah, Nazareno Paolocci and John P. Toscano.  (2021) Alkylsulfenyl Thiocarbonates: Precursors to Hydropersulfides Potently Attenuate Oxidative Stress. Chem. Sci.12, 8252-8259. []

Darcie H. Long and Craig A. Townsend (2021) Acyl Donor Stringency and Dehydroaminoacyl Intermediates in g-Lactam Formation by a Non-ribosomal Peptide Synthetase.” ACS-Chem. Biol. 16, 806-812  []

Michael J. Wheadon and Craig A. Townsend. (2021) Evolutionary and functional analysis of an NRPS condensation domain integrates b-lactam, D-amino acid, and dehydroamino acid synthesis. Proc. Natl Acad. Sci. 118, e2026017118 [doi:10.1073/pnas.2026017118]


Guan-Da Syu, Eric Johansen, Heng Zhu (2020)  Virion Display: A High-Throughput Method to Express Functional Membrane Proteins. Curr Protoc Mol Biol 132, e126 [doi: 10.1002/cpmb.126]

Schatzman SS, Peterson RL, Teka M, He B, Cabelli DE, Cormack BP, Culotta VC. (2020) Copper-only superoxide dismutase enzymes and iron starvation stress in Candida fungal pathogens. J. Biol. Chem. 295(2):570-583. [DOI: 10.1074/jbc.RA119.011084]

Henager SH, Henriquez S, Dempsey DR, Cole PA. (2020) Analysis of Site-Specific Phosphorylation of PTEN by Using Enzyme-Catalyzed Expressed Protein Ligation. ChemBioChem. 21(1-2):64-68. [DOI: 10.1002/cbic.201900316]

Abraham R, McPherson RL, Dasovich M, Badiee M, Leung AKL, Griffin DE. (2020) Both ADP-Ribosyl-Binding and Hydrolase Activities of the Alphavirus nsP3 Macrodomain Affect Neurovirulence in Mice. mBio.11;11(1).[DOI: 10.1128/mBio.03253-19]

Khodade VS, Pharoah BM, Paolocci N, Toscano JP. (2020) Alkylamine-Substituted Perthiocarbamates: Dual Precursors to Hydropersulfide and Carbonyl Sulfide with Cardioprotective Actions. Journal of the American Chemical Society. 142(9):4309-4316. [DOI: 10.1021/jacs.9b12180]

Cairns L, Patterson A, Weingartner KA, Koehler TJ, DeAngelis DR, Tripp KW, Bothner B, Kavran JM. (2020) Biophysical characterization of SARAH domain-mediated multimerization of Hippo pathway complexes in Drosophila. Journal of Biological Chemistry. 295(18):6202-6213. [DOI: 10.1074/jbc.RA120.012679]

Hutchinson MA, Deeyaa BD, Byrne SR, Williams SJ, Rokita SE. (2020) Directing Quinone Methide-Dependent Alkylation and Cross-Linking of Nucleic Acids with Quaternary Amines. Bioconjugate Chemistry. 31(5):1486-1496. [DOI: 10.1021/acs.bioconjchem.0c00166]

Syu GD, Dunn J, Zhu H. Developments and Applications of Functional Protein Microarrays. (2020) Molecular & Cellular Proteomics 19(6):916-927. [DOI: 10.1074/mcp.R120.001936]

Chu N, Viennet T, Bae H, Salguero A, Boeszoermenyi A, Arthanari H, Cole PA. (2020) The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling. eLife.[DOI: 10.7554/eLife.59151]

Cohen DR, Townsend CA. (2020) C-N-Coupled Metabolites Yield Insights into Dynemicin A Biosynthesis. ChemBioChem. 21(15):2137-2142.[DOI: 10.1002/cbic.202000177]

Gonzalez-Gil A, Li TA, Porell RN, Fernandes SM, Tarbox HE, Lee HS, Aoki K, Tiemeyer M, Kim J, Schnaar RL. (2020) Isolation, identification, and characterization of the human airway ligand for the eosinophil and mast cell immunoinhibitory receptor Siglec-8. Journal of Allergy and Clinical Immunology. August 2020 [DOI: 10.1016/j.jaci.2020.08.001]

Spisak S, Ostermeier M. (2020) Engineered protein switches for exogenous control of gene expression. Biochemical Society Transactions. 48(5):2205-2212. [DOI: 10.1042/BST20200441]

Byrne SR, Rokita SE. (2020) Unraveling Reversible DNA Cross-Links with a Biological Machine. Chemical Research in Toxicology. 33(11):2903-2913. [DOI: 10.1021/acs.chemrestox.0c00413]


Mazanek Z, Sohn J. (2019) Tracking the polymerization of DNA sensors and inflammasomes using FRET. Methods in Enzymology. 625:87-94. [DOI: 10.1016/bs.mie.2019.06.006.]

Dasovich M, Leung AKL. (2019) A Nucleolar PARtnership Expands PARP Roles in RNA Biology and the Clinical Potential of PARP Inhibitors. Molecular Cell. 75(6):1089-1091. [DOI: 10.1016/j.molcel.2019.09.001]

DeColli AA, Zhang X, Heflin KL, Jordan F, Freel Meyers CL. (2019) Active Site Histidines Link Conformational Dynamics with Catalysis on Anti-Infective Target 1-Deoxy-d-xylulose 5-Phosphate Synthase. Biochemistry 58(49):4970-4982. [DOI: 10.1021/acs.biochem.9b00878]

Sinner EK, Lichstrahl MS, Li R, Marous DR, Townsend CA. (2019) Methylations in complex carbapenem biosynthesis are catalyzed by a single cobalamin-dependent radical S-adenosylmethionine enzyme. Chemical Communications. 55(99):14934-14937. [DOI: 10.1039/c9cc07197k]

Okafor IC, Singh D, Wang Y, Jung M, Wang H, Mallon J, Bailey S, Lee JK, Ha T. (201) Single molecule analysis of effects of non-canonical guide RNAs and specificity-enhancing mutations on Cas9-induced DNA unwinding. Nucleic Acids Research. 47(22):11880-11888. [DOI: 10.1093/nar/gkz1058]

Ando Y, Elkayam E, McPherson RL, Dasovich M, Cheng SJ, Voorneveld J, Filippov DV, Ong SE, Joshua-Tor L, Leung AKL. (2019) ELTA: Enzymatic Labeling of Terminal ADP-Ribose. Molecular cell. 73(4):845-856.e5. [DOI: 10.1016/j.molcel.2018.12.022.]

Bartee D, Sanders S, Phillips PD, Harrison MJ, Koppisch AT, Freel Meyers C. (2019) Enamide Prodrugs of Acetyl Phosphonate Deoxy-d-xylulose-5-phosphate Synthase Inhibitors as Potent Antibacterial Agents. ACS Infectious Diseases. 5(3):406-417. [DOI: 10.1021/acsinfecdis.8b00307.]

Byrne SR, Yang K, Rokita SE. Effect of Nucleosome Assembly on Alkylation by a Dynamic Electrophile. (2019) Chemical Research in Toxicology. 32(5):917-925. [DOI: 10.1021/acs.chemrestox.9b00057]

Fernandez Garcia M, Moore CD, Schulz KN, Alberto O, Donague G, Harrison MM, Zhu H, Zaret KS. (2019) Structural Features of Transcription Factors Associating with Nucleosome Binding. Molecular Cell 75(5):921-932.e6. [DOI: 10.1016/j.molcel.2019.06.009]

Cole PA, Chu N, Salguero AL, Bae H. AKTivation mechanisms. Current opinion in structural biology. 2019 December;59:47-53. PubMed PMID:30901610; PubMed Central PMCID: PMC6752985; DOI: 10.1016/

Nye DB, Johnson EA, Mai MH, Lecomte JTJ. (2019) Replacement of the heme axial lysine as a test of conformational adaptability in the truncated hemoglobin THB1. (2019) J. Inorganic Biochemistry.  201:110824. [DOI: 10.1016/j.jinorgbio.2019.110824]


Singh D, Mallon J, Poddar A, Wang Y, Tippana R, Yang O, Bailey S, Ha T. (2018) Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1 (Cas12a). Proceedings of the National Academy of Sciences of the United States of America. 115(21):5444-5449.[DOI: 10.1073/pnas.1718686115]

Boucher LE, Hopp CS, Muthinja JM, Frischknecht F, Bosch J. (2018)Discovery of Plasmodium (M)TRAP-Aldolase Interaction Stabilizers Interfering with Sporozoite Motility and Invasion. ACS Infectious Diseases. 4(4):620-634. [DOI: 10.1021/acsinfecdis.7b00225]

Herbst DA, Huitt-Roehl CR, Jakob RP, Kravetz JM, Storm PA, Alley JR, Townsend CA, Maier T. (2018) The structural organization of substrate loading in iterative polyketide synthases. Nat. Chem. Biol. 14:474-479. [doi: 10.1038/s41589-018-0026-3]

Schatzman SS, Culotta VC.(2018)  Chemical Warfare at the Microorganismal Level: A Closer Look at the Superoxide Dismutase Enzymes of Pathogens. ACS Infect. Dis.  4:893–903. [doi: 10.1021/acsinfecdis.8b00026]

Singh D, Wang Y, Mallon J, Yang O, Fei J, Poddar A, Ceylan D, Bailey S, Ha T. (2018) Mechanisms of improved specificity of engineered Cas9s revealed by single-molecule FRET analysis. Nat. Struct. Mol. Biol. 25:347-354.  [doi: 10.1038/s41594-018-0051-7]

Cohen DR, Townsend CA. (2018) A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis. Nat. Chem. 10:231-236.  [doi: 10.1038/nchem.2876]

Cohen DR, Townsend CA. (2018) Characterization of an Anthracene Intermediate in Dynemicin Biosynthesis. Angew. Chem. Int. Ed. Engl. 57:5650-5654.  [doi: 10.1002/anie.201802036]

Saraiva RG, Huitt-Roehl CR, Tripathi A, Cheng YQ, Bosch J, Townsend CA, Dimopoulos G. (2018) Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin. Sci. Rep. 8:6176. [doi: 10.1038/s41598-018-24296-0]

Nye DB, Preimesberger MR, Majumdar A, Lecomte JTJ. (2018) Histidine-Lysine Axial Ligand Switching in a Hemoglobin: A Role for Heme Propionates. Biochemistry 57:631-644. [doi: 10.1021/acs.biochem.7b01155.]

Boucher LE, Hopp CS, Muthinja JM, Frischknecht F, Bosch J. (2018) Discovery of Plasmodium (M)TRAP-Aldolase Interaction Stabilizers Interfering with Sporozoite Motility and Invasion. ACS Infect. Dis. 4:620-634.  [doi: 10.1021/acsinfecdis.7b00225]


Sanders S, Vierling RJ, Bartee D, DeColli AA, Harrison MJ, Aklinski JL, Koppisch AT, Freel Meyers CL. (2017) Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase. ACS Infect. Dis. 3:467-478. [doi: 10.1021/acsinfecdis.6b00168]

Storm PA, Townsend CA. (2017) In trans hydrolysis of carrier protein bound acyl intermediates by CitA during citrinin biosynthesis. Chem. Commun. (Camb). 54:50-53.  [doi: 10.1039/c7cc07079a]

Kosowicz JG, Lee J, Peiffer B, Guo Z, Chen J, Liao G, Hayward SD, Liu JO, Ambinder RF. Drug Modulators of B Cell Signaling Pathways and Epstein-Barr Virus Lytic Activation. (2017) J Virol. 91(16).  [doi: 10.1128/JVI.00747-17.]

Barajas JF, Shakya G, Moreno G, Rivera H Jr, Jackson DR, Topper CL, Vagstad AL, La Clair JJ, Townsend CA, Burkart MD, Tsai SC. (2017) Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases. Proc. Natl. Acad. Sci. U S A. 114:E4142-E4148. [doi: 10.1073/pnas.1609001114]

Rossi DCP, Gleason JE, Sanchez H, Schatzman SS, Culbertson EM, Johnson CJ, McNees CA, Coelho C, Nett JE, Andes DR, Cormack BP, Culotta VC. (2017) Candida albicans FRE8 encodes a member of the NADPH oxidase family that produces a burst of ROS during fungal morphogenesis. PLoS Pathog. 13(12):e1006763. [doi: 10.1371/journal.ppat.1006763]

Preimesberger MR, Johnson EA, Nye DB, Lecomte JTJ. (2017) Covalent attachment of the heme to Synechococcus hemoglobin alters its reactivity toward nitric oxide. J Inorg Biochem.  177:171-182. [doi: 10.1016/j.jinorgbio.2017.09.018]

Head SA, Shi WQ, Yang EJ, Nacev BA, Hong SY, Pasunooti KK, Li RJ, Shim. JS, Liu JO. (2017) Simultaneous targeting of NPC1 and VDAC1 by itraconazole leads to synergistic inhibition of mTOR signaling and angiogenesis. ACS Chem Biol.12:174-182.

Shelat NY, Parhi S, Ostermeier M. (2017) Development of a cancer-marker activated enzymatic switch from the herpes simplex virus thymidine kinase. Protein Eng Des Sel. 30:95-103.

Yu H, Gonzalez-Gil A, Wei Y, Fernandes SM, Porell RN, Vajn K, Paulson JC, Nycholat CM, Schnaar RL. (2017) Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties. Glycobiology 27:657-668.

Ingavat N, Kavran JM, Sun Z, Rokita SE (2017) Active site binding is not sufficient for reductive deiodination by iodotyrosine deiodinase. Biochemistry 56:1130-1139.

Su Q, Boucher PA, Rokita SE (2017) Conversion of a dehalogenase to a nitroreductase by swapping its flavin cofactor with a 5-deazaflavin analog. (2017) Angew. Chem. Int. Ed. 56:10862-10866

Storm PA, Herbst DA, Maier T, Townsend CA. (2017) Functional and structural analysis of programmed C-methylation in the biosynthesis of the fungal polyketide citrinin. Cell Chem Biol. 24:316-325.


Henager S, Chu N, Chen Z, Bolduc DM, Dempsey DR, Hwang Y, Wells J, Cole PA (2016) Enzyme-catalyzed expressed protein ligation. Nature Methods 13: 925-927.

Nemeria NS, Shome B, DeColli AA, Heflin K, Begley TP, Freel Meyers CF, Jordan F. (2016) Competence of thiamin diphosphate-dependent enzymes with 2′-methoxythiamin diphosphate derived from bacimethrin, a naturally occurring thiamin anti-vitamin. Biochemistry 55:1135-1148.

Choi, JH, Xiong T, Ostermeier M. (2016) The interplay between effector binding and allostery in an engineered protein switch. Protein Sci. 25:1605-1616.

Steinberg B, Ostermeier M. (2016) Shifting fitness and epistatic landscapes reflect tradeoffs along an evolutionary pathway. J. Mol. Biol. 428:2730-2743,

Steinberg B, Ostermeier M (2016) Environmental changes bridge evolutionary valleys. Sci. Adv. 2:e1500921.

Shelat NY, Parhi S, Ostermeier M. (2016) A positive selection for nucleoside kinases in E. coli. PLoS One. 11:e0162921.

Saha S, Rokita SE (2016) An activator of an adenylation domain revealed by activity but not sequence homology. ChemBioChem 17:1818-1823.

Phatarphekar A, Rokita SE (2016) Functional analysis of iodotyrosine deiodinase from Drosophila melanogaster.  Protein Science 25:2187-2195.

Millikin R, Bianco CL, White C, Saund SS, Henriquez S, Sosa V, Akaike T, Kumagai Y, Soeda S, Toscano JP, Lin J, Fukuto JM. (2016) The chemical biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generation. Free Radic Biol Med. 97:136-47.

Hansen EC, Ransom M, Hesselberth JR, Hosmane NN, Zhang H, Capoferri AA, Drummond MB, Siliciano JM, Siliciano RF. Stivers JT (2016) Diverse fates of uracilated HIV DNA during infection of myeloid lineage cells. eLIFE 5:e18447.

Newman, AG. Townsend CA (2016) Molecular characterization of the cercosporin biosynthetic pathway in the fungal plant pathogen Cercospora nicotianae. (2016) J. Am. Chem. Soc. 138:4219-4228.

Barajas JF, Finzel K, Valentic TR, Shakya G, Gamarra N, Martinez D, Meier JL, Vagstad AL, Newman AG, Townsend CA, Burkart MD, Tsai S-C (2016) Structural and biochemical analysis of protein-protein interactions between the acyl carrier protein and product template domain. Angew. Chem. Int. Ed. 55:13005-13009.

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