January 30
WBSB 303

Faculty Speaker

Prof. Jamie Spangler (Chemical and Biomolecular Engineering) 
“Mechanism-driven design of antibodies for cancer immunotherapy”   

Research Update

Haley Tarbox (Fried Lab) 
“Investigating the Protein Conformational Landscape Associated with Cognitive Decline in Aging using Limited Proteolysis Mass Spectrometry”

Professional Development

Mitchell Porter (Schnaar Lab) 
“Alternative career paths – intellectual property”  

February 27
Remsen 233 

Independent Research Proposal

Brett O’Brien (Woodson Lab)
“Functional Analysis of pathogenic mutations in an Uncharacterized Mitochondrial Aminoacyl-tRNA Synthetase in Yeast”

Keynon Bell (Hristova Lab) 
“Investigating the Effects of Oxygen and Biofilm Composition on Bacteriophage Therapy Efficacy and Immunological Resistance”

RCR

Prof. Steve Rokita (Chemistry)
“Conflict Resolution”

April 3
WBSB 303

Faulty Speaker

 Prof. Bethany Powell Gray (Pharmacology)
“Tunable Oligonucleotides for Drug Delivery and Imaging”

Independent Research Proposal

Kimberly Lange (Kavran Lab) 

RCR/Professional Development

Prof. Rebecca Schulman (ChemBE)
“Data Handling”

May 1
Remsen 233

Independent Research Proposal

 Vincent Clark (Arroyo Lab)
“Achieving Controlled Release of High Molecular Weight Acids to Aid in Diabetic Wound Healing”

Research Update

Marnie Kotlyar (Liu Lab) 
“Demystifying the mechanism by which a GLUT1 inhibitor leads to NFAT/AP-1 blockade” 

Group Discussion

Student Feedback on CBI

January 31st
Remsen 233

Faculty Speaker

Prof. Marc Ostermeier (Chemical and Biomolecular Engineering) “What causes the fitness effects of mutations?”

Research Update

Jessica Dunn (Zhu lab) “Development of novel tools for highly multiplexed proteomics and analysis of transcriptional circuitry”

RCR

Prof. Netz Arroyo (Pharmacology and Molecular Sciences) “The Mentor-Mentee Duo: Responsibilities and Relationships”

February 28th
Rangos 490

Faculty Speaker

Prof. Scott Bailey (Biochemistry and Molecular Biology) “Towards Understanding the diversity of CRISPR Immune Systems”

Research Update

Isabel Uribe (Leung lab) “Connecting Size to Site: Developing MS-based Approaches to Characterize the Mono- and Poly(ADP-ribosyl)omes”

RCR

Prof. Ron Schnaar (Pharmacology and Molecular Sciences) “Dealing with Misconduct”

April 4th
Remsen 233

Faculty Speaker

Prof. Stephen Fried (Chemistry) “Folding the Proteome (Some Assembly Required)”

Research Update

Harrison Greenberg (Rokita lab) “Challenging reversible cross-links with molecular machines”

Professional Development/Group Discussion

Dr. Roshni Rao (Director of PHutures) “Doctoral Career Design- Available opportunities and Impact”

May 2nd
Big Abel (WBSB 303)

Faculty Speaker

Prof. Netz Arroyo (Pharmacology and Molecular Sciences) “Understanding the Mechanisms of Monolayer Decay in Electrochemical, DNA-based Biosensors”

Research Update

Mitchell Porter (Schnaar lab) “Decoding Cell Surface Glycan Regulation: Ganglioside Interactome Toolkit”   Eric Johansen (Zhu lab) “Applications of Virion Display technology”

Professional Development

Ryan Weeks “From Academia to Industry: Sustainable Lab Practices that Make a Difference”

September 13th

Faculty Speaker
Remsen 233
Prof. Sarah Woodson (Biophysics)
“sRNA finds its match with the Hfq chaperone”
Introduction to Dissertation Research Projects
Presented by the Second Year CBI Students

October 18th

Faculty Speaker
Remsen 233
Prof. Craig Townsend (Chemistry)
“Overview and Research Highlights”
Research Proposal
Haley Tarbox (Fried lab)
“Investigating the Mechanism of Surface Sensing of the Rcs Phosphorelay in E. coli”
Introduction to Dissertation Research Projects (continued)
Kim Lange
“Determining Complex Formation Between Fascin and MST”
RCR
Theranos: a case study (Discussions continued with Keila Sheetz)

November 15th

Faculty Speaker
Big Abel (WBSB 303)
Prof. Cynthia Wolberger (Biophysics and Biophysical Chemistry)
“Histone modifying enzymes: From structure to drug discovery”
Research Proposal
Marnie Kotlyar (Liu lab)
“Investigating the Functional Role of Bioactive Peptides Derives from Proteasome Degradation in Neurons”
Professional Development
Dr. Felix Yu (Technology Project Manager at KKR & Co.)
“Exploring Alternative Careers in Consulting and Technology”

December 13th

Big Abel (WBSB 303)
Faculty Speaker
Prof. Anthony Leung (Biochemistry and Molecular Biology)
“Poly(ADP-ribose) is a potent inducer of protein condensates implicated in neurodegeneration”
Research Proposal
Jonathan Mahlum (Arroyo lab)
“Harnessing Extracellular Electron Transfer of Anaerobic Ammonium Oxidation Bacteria”
RCR/Professional Development
Prof. Steve Rokita
“CBI of the future”

Monday, February 8

Research Update
Lauren Bambarger (Meyers lab)
“Pursuing a novel class of antimicrobials: DXP Synthase Inhibitors”

RCR
Mentor/Mentee Discussion (continued with Dr. Steve Rokita)

Faculty Speakers
Prof. Kalina Hristova (Material Science & Engineering)
“Studies of Cell Signaling at the Intersection of Biology, Chemistry, and Physics”

Professional Development
Prof. Steve Rokita
“Coping with the Pandemic”

Monday, March 8

Faculty Speaker
Prof. Dominique Frueh (Biophysics and Biophysical Chemistry)
“Protein dynamics as universal molecular sensors in nonribosomal peptide synthetases”

Research Update
Keila Sheetz (Hilser lab)
“Better together? Examining Potential Synergy Between Protein Stability Prediction Methods”

Erica Sinner (Townsend lab)
“Structural and Biochemical Insights into TokK, a Cobalamin Dependent Radical SAM Methyltransferase”

Professional Development
Dr. Adam Newman (Scientist, Bayer)
“What to Expect When You Move from Academia to Industry: A Biased Perspective”

Monday, April 12

Faculty Speaker
Prof. James Berger (Biophysics and Biophysical Chemistry)
“Small Molecule Metabolite Control of a DNA Disentangling Enzyme”

Research Update
Shaun Spisak (Ostermeier lab)
“Developing Positive and Negative Selections for dCas9 Activity”

Antonieta Salguero Rivera (Cole lab)
“Effects of C-terminal Post-translational Modifications on Akt1 Regulation”

Professional Development
Dr. Sabrina Schatzman (ORISE Postdoctoral Fellow, CDC)
“My experience as an ORISE Postdoctoral Fellow”

Monday, May 10

Faculty Speaker

Jun Liu (Pharmacology and Molecular Sciences)
“Rapafucins—Natural Products-Inspired Macrocycles as New Chemical Probes and Drug Leads”

Research Update
Tony Dorado (Barrow lab)
“Design and synthesis of a novel class of RNA polymerase I inhibitors”

Morgan Dasovich (Leung lab)
“Chemoenyzmatic strategies for exploring ADP-ribosylation”

Group Discussion
Prof. Steve Rokita (Program Feedback)

Monday, September 14

Faculty Speaker
J. Sohn (Biophysics & Biophysical Chemistry)
“Allosteric Regulation of cGAS”
Research Proposal
Eric Johansen (Zhu lab)
“Characterization of oncolytic HSV-1 T-VEC mediated immunogenic cell death against different types of cancer”
RCR/Professional Development
Steven Rokita (Chemistry)
“CBI Program Feedback”

Monday, October 19

Research Update
Blaze Pharoah (Toscano lab)
“Defining the Role of Persulfides in Cardiology”

Research Proposal
Mitchell Porter (Schnaar lab)
“Mechanistic Study into the Modulation of Praja-1 by 18:0/22:6-PA”
Group Discussion
“Confronting Institutional Racism”

Monday, November 16

Research Proposal
Isabel Uribe (Leung Lab)
“Investigating the Effect of AKAP11 O-GlcNAcylation on GSK-3β Signaling in Alzheimer’s Disease”
Faculty Speaker
James Barrow (Pharmacology & Molecular Sciences)
“Valium for the Gut – Peripherally-Restricted GABA-A Receptor Modulators”
Professional Development/Group Discussion
James Barrow (Pharmacology & Molecular Sciences)
“Intellectual Property: Can you get rich from your discoveries?”

Monday, December 14

Research Update
TJ Koehler (Kavran lab)
“Biochemical Characterization of LATS1 Kinase”
Research Proposal
Jessica Dunn (Zhu lab)
“Development and Characterization of a Proteolysis Targeting Chimeras (PROTACs) for the targeted degradation of Eyes Absent homolog 2 (EYA2)”
Professional Development/Group Discussion
Patrick McTamney, Senior Scientist at AstraZeneca
“Big Pharma 101”

Monday, January 11

Faculty Speaker
Caren Meyers (Pharmacology & Molecular Sciences)
“Targeting bacterial metabolic adaptation: inhibition of DXP synthase”
Research Proposal
Harry Greenberg (Rokita lab)
“Disentangling the interplay between multiple post-translational modifications of α-synuclein and their role in the pathogenesis of Parkinson’s Disease”
Professional Development
Steve Rokita (Chemistry)
Mentor/Mentee Discussion

Monday, February 10th

Faculty Speaker
Big Abel Library
Prof. Jennifer Kavran (Biochemistry & Molecular Biology)
“Proximity as a unifying mechanism for Mst1/2 Activation”
Research Update
Zachary Mazanek (Sohn Lab)
“Defining the mechanism and specificity of inflammasome
regulation by POPs”
RCR/Group Discussion
Prof. Steve Rokita (Chemistry)
“Scientific Record Keeping”

Monday, March 9th

Faculty Speaker
Remsen 233
Prof. Rebecca Schulman (ChemBE)
TBA
Research Update
Ryan Weeks (Ostermeier Lab)
“Development of a selection for RNase III activity”
John Mallon (Bailey Lab)
“PAM Profiling and Interference Activation in a I-B CRISPR-Cas System”
RCR/Group Discussion
Prof. Steve Rokita (Chemistry)
“Sense of Belonging”

Monday, April 6th

Faculty Speaker
Big Abel Library
Prof. James Barrow (Pharmacology)
Research Update
TJ Koehler (Kavran Lab)
Professional Development
Zach Mazanek (Sohn Lab)
“CBI and the Law”

Friday, May 1st

Faculty Speaker
Remsen 233
Prof. Caren Meyers (Pharmacology)
Research Update
Blaze Pharoah (Toscano Lab)
Program Feedback
Prof. Steve Rokita (Chemistry)

Monday, September 9th

Research Proposal
Remsen 233
Keila Sheetz (Hilser Lab)
“Characterizing and revising the serotype of a therapeutic class of adeno-associated viruses for the treatment of Parkinson’s Disease”
Professional Development/Group Discussion
Steve Rokita (Chemistry)
“Civility in Science and Life”
Faculty Speaker
Christian Kaiser (Biology)
“Dissecting protein folding with optical tweezers”

Monday, October 14th

Faculty Speaker
Rangos 590
Xiongyi Huang (Chemistry)
“Bringing New Catalytic Functions to Enzymes by Bridging Synthetic Chemistry and Biology”
Research Proposal
Lauren Bambarger (Meyers Lab)
“Elucidating the role of Thalassiosira pseudonana Lhcx6 in nonphotochemical quenching: implications of ocean acidification on photoprotection”
Professional Development
Steve Rokita (Chemistry)
“Effective Communication”

Monday, November 11th

Faculty Speaker
Rangos 590
Valeria Culotta (Biochemistry & Molecular Biology)
“Metals, Microbes and Infectious disease“
Research Proposal
Tony Dorado (Barrow Lab)
“Determination of the Molecular Target and Mechanism of Action of Bisacodyl”
Professional Development
John Sampson (Director, JHU Writing Center)
“The Johns Hopkins Writing Center: Information and Best Practices”

Monday, December 9th

Faculty Speaker
Remsen 233
Marc Ostermeier (ChemBE)
“Collateral fitness effects of mutations”
Research Proposal
Shaun Spisak (Ostermeier Lab)
“Characterizing the Biosynthesis of Lassomycin, a Novel Peptide Antibiotic”
Professional Development/Group Discussion
Dr. Callie Huitt-Roehl (Paragon Bioservices)
“Contract Development and Manufacturing Organizations and Their Role in the Future of Pharma”

Monday, January 13th

Faculty Speaker
Remsen 233
Stephen Fried (Chemistry)
“Folding the Proteome (Some Assembly Required)”
Research Proposal
Katherine Miller (Schulman Lab)
“Stucture-Function Studies of Glycosylated VEGF with Glycosaminoglycans and Proteases of the Extracellular Matrix”
Professional Development/Group Discussion
Daryl Guthrie (NIH)
“From JHU to NIDA IRP and beyond”

Monday, May 6

Faculty Speaker
Prof. Philip Cole (Pharmacology)
“Chemical approaches to sorting out reversible lysine modifications”
Research Updates
Antonieta Salguero-Rivera (Cole Lab)
“Effects of C-terminal Tail Phosphorylation on Akt Activation”
James Rives (Hilser Lab)
“The thrill of the SNase”
Program Feedback
Prof. Steve Rokita (Chemistry)
“CBI Program Feedback”

Monday, April 8

Faculty Speaker
Prof. Netzahualcóyotl Arroyo (Pharmacology)
“Feedback-Control of Plasma Drug Levels Enabled by Continuous, In-Vivo Drug Measurements”
Research Updates
Stephanie Henriquez (Meyers Lab)
“Toward Enhancing Uptake of DXPS Inhibitors in Pathogenic Bacteria”
Erica Sinner (Townsend Lab)
“Deciphering the biosynthetic logic and unique enzymatic construction of carbapenems”
Group Discussion
Prof. Steve Rokita (Chemistry)
“Responsible Conduct in Research: Peer Review”

Monday, March 11

Research Updates
Michael Wheadon (Townsend Lab)
“Insights into the evolutionary origins of the nocardicin NRPS and its unique enzymatic capabilities”
Jamie Alley (Townsend Lab)
“Gene Knockouts in the Dynemicin Biosynthetic Cluster and Accumulating Intermediates”
Professional Development/Group Discussion
Dr. Kate Bradford (Assistant Director of Career Services)
“Building a Professional Online Presence”

Monday, Feb. 11

Faculty Speaker
Prof. Cynthia Wolberger (Biophysics & Biophysical Chemistry)
“How histone ubiquitination activates a methyltransferase”
Professional Development
Rick Hooy (Sohn Lab)
“What I Learned From My Postdoc Search”
Group Discussion
Prof. Steve Rokita (Chemistry)
“Responsible Conduct in Research: Authorship and Peer Review”

Monday, Jan. 14

Faculty Speaker
Prof. Scott Bailey (BMB)
“An update on CRISPR’s day job”
Research Updates
Shane Byrne (Rokita Lab)
“Processing DNA Lesions Induced by a Dynamic Electrophile”
Katelyn Jackson (Bailey Lab)
“The SOS Repair Pathway and Induced Mutagenesis in Pseudomonas aeruginosa”
Professional Development/Group Discussion
Sabrina Schatzman (Culotta Lab)
“Networking and Informational Interviews”

Monday, Dec. 10

Faculty Speaker
Prof. Anthony Leung (Biochemistry)
“ELTA: Novel platform technology to study ADP-ribose metabolism”
Research Proposal
Morgan Dasovich (Leung Lab)
“Decoding the language of CpG modification with chemical proteomics”
Professional Development/Group Discussion
Dr. Ananya Majumdar
“Facilitating Research, Training and Education via the Biomolecular NMR Core Facility at Hopkins”

Monday, Nov. 12

Faculty Speaker
Prof. Ron Schnaar (Pharmacology)
“Glycan recognition: from the brain to the airways…. and back.​”
Prof. Greg Bowman (Biophysics)
“How chromatin remodelers bind and reposition nucleosomes”
Prof. Rebecca Schulman (ChemBE)
“In vitro synthetic Biology with nucleic acids”
Professional Development/Group Discussion
Prof. Steve Rokita
“RCR: Common misconceptions of data analysis: P-hack”

Monday, Oct. 8

Faculty Speaker
Prof. J. Sohn (Biophysics)
“Analogue signaling: how to tune an innate immune pathway using an allosteric enzyme”
Research Proposal
TJ Koehler (Kavran Lab)
“A Mechanistic Link Between Ca2+ Channel Activity and G-protein Signaling in PC1 PC2 Hetero-Oligomers”
Professional Development/Group Discussion
Prof. Robert Cole
“Careers in High-tech Instrumentation Centers”

Monday, Sept. 17

Faculty Speaker
Prof. Stephen Fried (Chemistry)
“How Do Proteins Fold in Real Life?”
Research Proposal
Ryan Weeks (Ostermeier Lab)
“An in vitro strategy to clarify how D-amino acids cause ribosomal stalling”
Professional Development
Prof. Steve Rokita
“Care and Feeding of Your Advisor”

Friday, May 4

Faculty Speaker
Sarah Woodson (Biophysics)
“RNA chaperone brings speed dating to small RNAs”
Research Updates
Felix Yu (Liu Lab)
“Introduction of WL5A5: A novel small molecule linking mechanotransduction and regenerative medicine”
Rick Hooy (Sohn Lab)
Professional Training
Dr. Joshua Weiyuan, Chief Scientific Officer at PathoVax LLC & Adjunct Assistant Professor of Pathology at Johns Hopkins Medicine
“Post- PhD life as a non-traditional academic”

Monday, April 9

Research Updates
Ryan Porell (Schnaar Lab)
“Sulfated Glycans Put the Brakes on Airway Inflammation”
Cedric Moore (Zhu Lab)
“New tools for uncovering transcriptional circuitry”
Group Discussion
Professor Steve Rokita
“Program Feedback with Students”

Monday, March 12

Faculty Speaker
Craig Townsend (Chemistry)
“Highlights From Recent Research”
Research Updates
Doug Cohen (Townsend Lab)
“Insights into anthraquinone-fused enediyne assembly through biosynthetic investigations of dynemicin A”
Zach Mazanek (Sohn Lab)
“Pyrin Domain Only Proteins (POPs) attenuate inflammasome assembly”

Monday, Feb. 12

Research Updates
John Mallon (Bailey Lab)
Brandon Peiffer (Liu Lab)

Monday, Jan. 22

Research Proposals
Jamie Alley and Erica Sinner (Townsend Lab)

Thursday, Jan. 11

Research Proposal
Katelyn Jackson (Bailey Lab)
Group Discussion
“The Mistrust of Science” and “Graduate Biomedical Science Education Needs a New Philosophy”

Monday, Dec. 11

Faculty Speaker
Marc Ostermeier (Chemical & Biomolecular Engineering)
“RNA-Programmed DNA Methylation”
Research Proposal
Shane Byrne (Rokita Lab)
“Mechanistic Investigations to Enhance the Rate of Cysteine Protease-Like DNAzymes”
Professional Training
Felix Yu (Liu Lab), Sabrina Schatzman (Culotta Lab), Ryan Porell (Schnaar Lab)
“An Elevator Pitch Practicum”

Monday, Nov. 13

Faculty Speaker
James Berger (Biophysics)
“Berger Lab Research”
Research Proposal
Antonieta Salguero Rivera (Cole Lab)
“Musashi-1, a potential modulator of the Zika virus genome replication and translation”
Professional Training
Justin Lorts, Senior Counselor, JHU Career Center
Pat Phelps, Director of Professional Development and Careers Office, JHMI
“Career and Professional Development Opportunities at Hopkins”

Monday, Oct. 16

Faculty Speaker
Juliette Lecomte (Biophysics)
“Hemoglobin chemistry: Adding molecular touches to a family portrait”
Research Proposal
Stephanie Henriquez (Meyers Lab)
Professional Training
Peter Scholl, Research Chemist, Food and Drug Administration
“From Ivory Tower to Concrete Bunker: How I Went from Homewood to the FDA”

Monday, Sept. 18

Faculty Speaker
Jennifer Kavran (Biochemistry & Molecular Biology)
“Regulation of Hippo Pathway Signaling”
Research Proposal
Michael Wheadon (Townsend Lab)
“Determining the scope and influence of interactions between the Helicobacter pylori virulence factor CagA and E-cadherin”
Professional Training
Caroline Pounds, Assistant Director, Career Resources for Biomedical Trainees
“The BCI Internship Program”