Chemistry-Biology Interface Program > People
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faculty

Netz Arroyo

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Research Interests: Development of biology-inspired electrochemical sensors to enable 1) direct detection of disease markers and drugs in biological fluids for decentralized health monitoring and 2) continuous, real-time measurements of molecules in situ in the body.

James Barrow

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Research Interests: Medicinal chemistry and drug discovery, especially for diseases of the central nervous system

James Berger

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Research Interests: Structural and catalytic mechanisms of nucleic-acid machines and assemblies; control of DNA replication and chromosome superstructure; small-molecule and biological regulatory mechanisms.

Greg Bowman

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Research Interests: Mechanisms of nucleosome remodeling by ATPase motors and other chromatin enzymes

Stephen Fried

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Research Interests: Folding and assembly of proteins and molecular machines in vivo; crosslinking mass spectrometry; ancient proteins and the origins of life; synthetic biology and directed evolution

David Goldberg

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Research Interests: Bioinorganic chemistry, synthetic analogs of metalloenzymes, synthesis and reactivity of heme and nonheme transition metal complexes, biomimetic small molecule activation (e.g. dioxygen, nitric oxide, hydrogen sulfide)

Bethany Powell Gray

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Research Interests: Nucleic acid chemistry and biology in order to create safer drugs and tunable imaging agents for disease detection

Marc Greenberg

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Research Interests: Chemical, biochemical, and biological studies on nucleic acid damage and DNA repair in free DNA and nucleosomes, design of radiosensitizing agents, inhibitors of DNA repair enzymes, and molecules that enable the spatiotemporal control of nucleic acid structure

Kalina Hristova

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Research Interests: Chemistry at biological interfaces, cell signaling, biochemistry of membrane proteins, quantitative fluorescence microscopy.

Xiongyi Huang

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Research Interests: Our lab harnesses the power of directed evolution to develop new enzymes to solve outstanding problems at the frontiers of chemistry and biology

Anthony Leung

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Research Interests: Biology behind poly(ADP-ribose) (PAR)—the third polynucleotide besides DNA and RNA. Research includes (1) developing new chemical and proteomics tools to study PAR, (2) identifying predictive biomarkers for cancer therapy with PAR polymerase (PARP) inhibitors, and (3) discovering novel roles of PAR in non-coding RNA biology and non-membranous cellular structures

Jun Liu

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Research Interests: Use of small molecules as probes to elucidate mechanisms of signal transduction; angiogenesis and cell proliferation

Caren Freel Meyers

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Research Interests: Development of antibiotic prodrug strategies; study of bacterial isoprenoid and vitamin biosynthesis as antibacterial targets

Steve Rokita

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Research Interests: Sequence and conformation specific reactions of nucleic acids; enzyme-mediated activation of substrates and coenzymes for dehalogenation

Ron Schnaar

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Research Interests: Cell surface molecular interactions (cell-cell recognition) and the control of cell behaviors in the nervous system (axon regeneration) and immune system (inflammation); Glycobiology

Rebecca Schulman

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Research Interests: In vitro synthetic biology for the design synthetic devices, materials and cells using ideas from DNA nanotechnology and systems chemistry

Jungsan Sohn

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Research Interests: Mechanistic enzymology and X-ray crystallography; structure and function of allosterically regulated biological stress-sensors

Jamie Spangler

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Research Interests: Engineering new proteins that modulate the immune response for targeted disease therapy. Synthesizing tools and techniques from structural biology, molecular engineering, and translational immunology, the Spangler lab seeks to understand the mechanisms underlying protein activity in order to design effective immunotherapeutics.

John Toscano

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Research Interests: The fundamental chemistry and biology of physiologically important signaling molecules including nitroxyl (HNO), hydrogen sulfide (H2S) and related reactive sulfur species including hydropersulfides (RSSH)

Craig Townsend

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Research Interests: Natural product chemistry, enzymology and molecular biology, fatty acid synthase inhibitors for cancer, tuberculosis and obesity

Cynthia Wolberger

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Research Interests: Biochemical, biophysical and structural studies on enzymes involved in ubiquitin signaling and transcription regulation

Sarah Woodson

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Research Interests: RNA folding and catalysis; dynamics of small regulatory RNAs; mechanism of 30S ribosome assembly by time resolved footprinting

Heng Zhu

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Research Interests: Develops and applies the protein chip technology to investigate important biological questions and to help clinical research. Research focus includes networks and pathways of protein posttranslational modifications, gene transcription regulatory networks, pathogen-host interaction networks, and biomarker discovery.

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