Publications

Sample publications from CBI students and affiliates.

2017

Head SA, Shi WQ, Yang EJ, Nacev BA, Hong SY, Pasunooti KK, Li RJ, Shim. JS, Liu JO. (2017) Simultaneous targeting of NPC1 and VDAC1 by itraconazole leads to synergistic inhibition of mTOR signaling and angiogenesis. ACS Chem Biol.12:174-182.

Shelat NY, Parhi S, Ostermeier M. (2017) Development of a cancer-marker activated enzymatic switch from the herpes simplex virus thymidine kinase. Protein Eng Des Sel. 30:95-103.

Yu H, Gonzalez-Gil A, Wei Y, Fernandes SM, Porell RN, Vajn K, Paulson JC, Nycholat CM, Schnaar RL. (2017) Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties. Glycobiology 27:657-668.

Ingavat N, Kavran JM, Sun Z, Rokita SE (2017) Active site binding is not sufficient for reductive deiodination by iodotyrosine deiodinase. Biochemistry 56:1130-1139.

Su Q, Boucher PA, Rokita SE (2017) Conversion of a dehalogenase to a nitroreductase by swapping its flavin cofactor with a 5-deazaflavin analog. (2017) Angew. Chem. Int. Ed. 56:10862-10866

Storm PA, Herbst DA, Maier T, Townsend CA. (2017) Functional and structural analysis of programmed C-methylation in the biosynthesis of the fungal polyketide citrinin. Cell Chem Biol. 24:316-325.

2016

Henager S, Chu N, Chen Z, Bolduc DM, Dempsey DR, Hwang Y, Wells J, Cole PA (2016) Enzyme-catalyzed expressed protein ligation. Nature Methods 13: 925-927.

Nemeria NS, Shome B, DeColli AA, Heflin K, Begley TP, Freel Meyers CF, Jordan F. (2016) Competence of thiamin diphosphate-dependent enzymes with 2′-methoxythiamin diphosphate derived from bacimethrin, a naturally occurring thiamin anti-vitamin. Biochemistry 55:1135-1148.

Choi, JH, Xiong T, Ostermeier M. (2016) The interplay between effector binding and allostery in an engineered protein switch. Protein Sci. 25:1605-1616.

Steinberg B, Ostermeier M. (2016) Shifting fitness and epistatic landscapes reflect tradeoffs along an evolutionary pathway. J. Mol. Biol. 428:2730-2743,

Steinberg B, Ostermeier M (2016) Environmental changes bridge evolutionary valleys. Sci. Adv. 2:e1500921.

Shelat NY, Parhi S, Ostermeier M. (2016) A positive selection for nucleoside kinases in E. coli. PLoS One. 11:e0162921.

Saha S, Rokita SE (2016) An activator of an adenylation domain revealed by activity but not sequence homology. ChemBioChem 17:1818-1823.

Phatarphekar A, Rokita SE (2016) Functional analysis of iodotyrosine deiodinase from Drosophila melanogaster. Protein Science 25:2187-2195.

Millikin R, Bianco CL, White C, Saund SS, Henriquez S, Sosa V, Akaike T, Kumagai Y, Soeda S, Toscano JP, Lin J, Fukuto JM. (2016) The chemical biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generation. Free Radic Biol Med. 97:136-47.

Hansen EC, Ransom M, Hesselberth JR, Hosmane NN, Zhang H, Capoferri AA, Drummond MB, Siliciano JM, Siliciano RF. Stivers JT (2016) Diverse fates of uracilated HIV DNA during infection of myeloid lineage cells. eLIFE 5:e18447.

Newman, AG. Townsend CA (2016) Molecular characterization of the cercosporin biosynthetic pathway in the fungal plant pathogen Cercospora nicotianae. (2016) J. Am. Chem. Soc. 138:4219-4228.

Barajas JF, Finzel K, Valentic TR, Shakya G, Gamarra N, Martinez D, Meier JL, Vagstad AL, Newman AG, Townsend CA, Burkart MD, Tsai S-C (2016) Structural and biochemical analysis of protein-protein interactions between the acyl carrier protein and product template domain. Angew. Chem. Int. Ed. 55:13005-13009.

Panja S, Paul R, Greenberg MM, Woodson SA. (2016) Light-triggered RNA annealing by an RNA chaperone. Angew Chem Int Ed Engl. 54:7281-7284.

Reiter KH, Ramachandran A, Xia X, Boucher LE, Bosch J, Matunis MJ. (2016) characterization and Structural Insights into Selective E1-E2 Interactions in the Human and Plasmodium falciparum SUMO Conjugation Systems. J Biol Chem. 291:3860-3870.

Mallon J, Bailey S. (2016) A molecular arms race: new insights into anti-CRISPR mechanisms. Nat Struct Mol Biol. 23:765-766.

Kuznedelov K, Mekler V, Lemak S, Tokmina-Lukaszewska M, Datsenko KA, Jain I, Savitskaya E, Mallon J, Shmakov S, Bothner B, Bailey S, Yakunin AF, Severinov K, Semenova E. (2016) Altered stoichiometry Escherichia coli cascade complexes with shortened CRISPR RNA spacers are capable of interference and primed adaptation. Nucleic Acids Res. 44:10849-10861.

Moore CD, Ajala OZ, Zhu H. (2016) Applications in high-content functional protein microarrays. Curr Opin Chem Biol. 30:21-27.

2015

Boucher LE, Bosch J. (2015) The apicomplexan glideosome and adhesins -structures and function. J Struct Biol. 190:93-114.

Zuckerman DM, Boucher LE, Xie K, Engelhardt H, Bosch J, Hoiczyk E. (2015) The bactofilin cytoskeleton protein BacM of Myxococcus xanthus forms an extended β-sheet structure likely mediated by hydrophobic interactions. PLoS One 10:e0121074.

Rice SL, Boucher LE, Schlessman JL, Preimesberger MR, Bosch J, Lecomte JT. (2015) Structure of Chlamydomonas reinhardtii THB1, a group 1 truncated hemoglobin with a rare histidine-lysine heme ligation. Acta Crystallogr F Struct Biol Commun. 71:718-725.

Bartee D, Morris F, Al-Khouja A, Freel Meyers CL (2015) Hydroxybenzaldoximes Are D-GAP-competitive inhibitors of E. coli 1-deoxy-D-xylulose-5-phosphate synthase. Chembiochem. 16:1771-1781.

Cravens SL, Schonhoft JD, Rowland MM, Rodriguez AA, Anderson BG, Stivers JT. (2015) Molecular crowding enhances facilitated diffusion of two human DNA glycosylases. Nucleic Acids Res.43:4087-4097.

Gaudelli NM, Long DH, Townsend CA. (2015) β-Lactam formation by a nonribosomal peptide synthetase during antibiotic biosynthesis. Nature 520:383-387.

Huitt-Roehl CR, Hill EA, Adams MM, Vagstad AL, Li JW, Townsend CA. (2015) Starter unit flexibility for engineered product synthesis by the nonreducing polyketide synthase PksA. ACS Chem Biol. 10:1443-1449.

Gonzalez-Gil A, Porell R, Fernandes SM, Aoki K, Tiemeyer M, Schnaar RL. (2015) “Siglec-8 binds to sialylated keratan sulfate chains on aggrecan extracted from human airways” Glycobiology 25:1249.

Zuckerman DM, Boucher LE, Xie K, Engelhardt H, Bosch J, Hoiczyk E. (2015) The bactofilin cytoskeleton protein BacM of Myxococcus xanthus forms an extended β-sheet structure likely mediated by hydrophobic interactions. PLoS One 10:e0121074.

Boucher LE, Bosch J. (2015) The apicomplexan glideosome and adhesins – structures and function. J Struct Biol. 190:93-114.

Jia Y, Yu H, Fernandes SM, Wei Y, Gonzalez-Gil A, Motari MG, Vajn K, Stevens WW, Peters AT, Bochner BS, Kern RC, Schleimer RP, Schnaar RL. (2015) Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells. J Allergy Clin Immunol. 135:799-810.